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KMID : 1146920180480030393
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Journal of Pharmaceutical Investigation
2018 Volume.48 No. 3 p.393 ~ p.407
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Preparation and characterization of transdermal mediated microemulsion delivery of T4 bacteriophages against E.coli bacteria: a novel anti-microbial approach
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Rastogi Vaibhav
Yadav Pragya
Verma Navneet
Verma Anurag
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Abstract
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The objective of this study was to design a novel microemulsion system for transdermal delivery of natural antimicrobial agent, i.e. bacteriophage (T4) specifically lysing E. coli bacteria. Pseudoternary phase diagrams were constructed and various formulations were prepared using a combination of ethyl oleate (oil), Tween 80:Span 20 (surfactant mixture) and water (aqueous phase). Developed formulations were subjected to physicochemical characterization, ex vivo and thermodynamic stability studies, skin irritation and histology studies. All the formulations had small droplet size (150?320nm), uniform size distribution (PI?
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KEYWORD
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Microemulsion, T4 bacteriophage, Transdermal delivery, E. coli, Antimicrobial
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